The opening of this film we are introduced to Dr. Heiter (Dieter Laser) who we think is a killer as we get to see him aim a gun at a trucker before breaking and starting a scene to introduce our two female leads Lindsey (Ashley C. Williams) and Jenny (Ashlynn Yennie). They are two American girls on a walk about in Europe and preparing to head to a party in the German countryside. This leads to the inevitable flat tire and then leaving the vehicle because there is no cell phone service to look for a house to call for help. They stumble upon Dr. Heiters home and he invites them in in his strange and off putting way. He says he will call for the rent a car service people but fakes the call from the other room while drugging the water he gets for the girls. When they are captured and drugged and then wake up they are in restraints, and laying with the big old trucker in what looks like an operating room. Scared and crying they watch in horror as the trucker is killed because as the Doctor says "One of these thing does not match. So next we have the doctor arriving with a new body of a young Japanese man Katsuro (Akihiro Kitamura), who has been tranquilizer darted. Now that all three parts have been procured Heiter explains to them that he is formerly the leading doctor for separating Siamese twins but now he wants to do the reverse. He wants to create a human centipede. He will attach the lips of one to the ass of the other and so forth creating a living human centipede with a singular digestive tract.
Naturally the captives are horrified and Lindsey successfully frees herself but not being able to bring herself to leave her friend she is recaptured and is promised the middle spot for the trouble she caused. The operation proceeds and it is a nasty thing this guy does, cutting knee tendons so the victims can't stand and attaching Lindsey's face to the ass of Katsuro while attaching Jenny's Face to Lindsey's behind. Absolute gross to look at we are subjected to the doctor then trying to train them like a dog. We get the requisite shitting in Lindsey's mouth scene and then the climax, when a couple of cops investigating the disappearance of the girls in the area find the doctor strange. I won't discuss the actual ending but I was left feeling like redemption of any kind was never in the plans for any character in this film. So strange and disturbing just talking to my wife about it left her with nightmares. A passing grade for the shocking grossness of the idea but really the film does not have any character paths that grow, only suffering so in the end not a great movie.